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Mechanoadaptation in Skeletal Tissues

Bone adapts to the mechanical environment, building bone with increased load and resorbing bone with decreased load. We are exploring the effects across length scales (whole bone, tissue, cell, molecule) in humans and animal models.

Multiscale Mechanics of Skeletal Tissues

Bone as a material is strong (carry a lot of load) and tough (bend without breaking). The toughness results from organization of the bone matrix from the molecular level to the whole bone. We explore how pathological changes, such as genetic defects, affect mechanical properties of the bone.

Advanced Skeletal Technologies

We are developing new techniques for examining and measuring the musculoskeletal system. We use novel animal models, develop computational methods, and build hardware to explore aspects of the musculoskeletal system.



Contact Dr. Sandra J. Shefelbine (Department of Mechanical and Industrial Engineering):
(617) 373-3199
Mailing Address
334 Snell Engineering Center
Northeastern University
360 Huntington Ave
Boston, MA 02115